Current Issue : October-December Volume : 2013 Issue Number : 4 Articles : 4 Articles
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using a combination of super disintegrating agents for enhancing the dissolution rate. Recently Fast Disintegrating Tablets (FDT) have started gaining popularity and acceptance as Novel Drug Delivery Systems (NDDS), because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as a bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Ac-di-sol (CCS), Polyplasdone–XL (CPV) and Primojel (SSG) were used as super disintegrating agents individually and in combinations of two super disintegrants (CCS: CPV; CCS: SSG and CPV: SSG) in the ratio 1:1 respectively for to study the effect of combination on the physical and dissolution parameters of the, while Mannitol (Pearlitol SD 200) is used as diluent. Direct compression technique was used as it requires conventional tablet machinery and thus process is economical. Formulations containing combination of super disintegrants CCS: CPV in the ratio 1:1 show rapid in-vitro and in-vivo dispersion time and faster dissolution rate as compared to other formulations....
Nimesulide (N-4’-nitro-2’-phenoxyphenyl methane sulfonamide) is weakly acidic nonsteroidal anti-inflammatory drug (NSAID). Like many other NSAIDs, nimesulide is also very sparingly soluble in water. The very poor aqueous solubility and wettability of these drugs gives rise to difficulties in pharmaceutical formulations for oral or parenteral delivery, which may lead to variable bioavailability. The most important work on these drawbacks by increasing aqueous solubility of these drugs. The present work therefore aims to formulate Nimesulide immediate release tablets, by incorporation of super disintegrants in the formulation and evaluate overall efficiency of them. The tablets were prepared by direct compression method. The nimesulide-β-cyclodexrtin 1:2 M complex was prepared by Kneaded system and compressed on a Rinek single stroke punch machine. Hardness, friability, weight variation were within limits. Disintegration time of all formulations was within 15 min and dissolution profile of different formulations showed release complies with BP specifications....
The purpose of this research was to develop Mouth dissolving tablets of Escitalopram oxalate using natural superdisintegrants (Abelmuscus esculentus and Trigonella foenum graceum) in different concentrations. Mucilage of Abelmuscus esculentus and seeds of Trigonella foenum graceum were extracted, evaluated for the organoleptic, physicochemical and phytochemical parameters. The dried mucilage was used as superdisintegrant for the preparation of mouth dissolving tablets by direct compression method. The blends were evaluated for the precompressional parameters and all the formulations were found to possess good flow properties. Tablets were compressed by direct compression technique, evaluated for weight variation, hardness, thickness, friability, water absorption, disintegration time, dispersion time, drug content and dissolution studies. The drug release profiles of the two superdisintegrants were compared and the optimized formula was subjected to wet granulation using PVP in ethanol as the dry binder. The results showed that the tablets containing dried mucilage of Abelmuscus esculentus as superdisintegrant using direct compression as the best formula and it followed first order release kinetics. Among ten formulations F5 showed highest drug release of 98.24 % than other formulations. The tablets were found to be stable during the accelerated stability studies conducted for three months at 40±2°C/75±5% RH....
Mucilages are widely used natural materials for conventional as well as for novel dosage forms. These natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. They can also be modified in different ways to obtain desired formulation for drug delivery systems and thus can compete with the available synthetic excipients. The present study was undertaken to isolate and characterize the mucilage of Calendula for its adhesive properties. The mucilage was isolated from the Calendula petals by aqueous extraction method and characterized for various physiochemical parameters such as solubility, pH, loss on drying, swelling index, test for carbohydrates, test for tannins, test for chloride, test for sulfate, viscosity, total carbohydrates content, and sugar analysis using thin layer chromatography. The mucilage was further characterized for flow properties as well as for its adhesive properties. The yield of mucilage was 10-11 % w/w. The isolated mucilage showed good physicochemical characteristics, flow properties and adhesion characteristics. Thus, from the studies, it is concluded that Calendula mucilage can be used as mucoadhesive component in pharmaceutical formulations due to its adhesive characteristics....
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